"Burn the Witch" is set in Reverse London, a hidden mirror version of the city where dragons, invisible to ordinary humans, coexist with the population. The story revolves around Noel Niihashi and Ninny Spangcole, two witches working for Wing Bind, an organization responsible for managing and protecting dragons. Their duties involve capturing rogue dragons and maintaining the balance between the human and dragon worlds.

Noel and Ninny are assigned to handle various dragon-related incidents, often involving dangerous or unpredictable creatures. Their partnership is tested when they encounter a powerful and rare dragon known as the Dark Dragon, which poses a significant threat to Reverse London. The narrative delves into their efforts to contain this threat while navigating the complexities of their roles within Wing Bind.

The series explores the dynamics between Noel and Ninny, highlighting their contrasting personalities and approaches to their work. Noel is methodical and reserved, while Ninny is more impulsive and outspoken. Their interactions provide both tension and camaraderie as they face increasingly perilous situations.

Key plot points include the discovery of a mysterious dragon egg, the emergence of a new threat from within Wing Bind, and the revelation of deeper connections between the characters and the dragons they manage. The story balances action, supernatural elements, and character development, offering a blend of high-stakes missions and personal growth.

"Burn the Witch" presents a self-contained narrative within the larger universe of its parent series, "Bleach," but stands on its own with its unique setting and focus on dragons and witches. The series maintains a brisk pace, ensuring that each episode advances the plot while providing insight into the world of Reverse London and its inhabitants.