"Mobile Suit Gundam 00I 2314" is a manga set in the "Mobile Suit Gundam 00" universe, taking place in the year 2314, two years after the events of the second season of the anime. The story explores the aftermath of the Celestial Being's efforts to eradicate war through armed intervention and the establishment of the Earth Sphere Federation. The world is now in a fragile state of peace, but tensions persist as humanity adjusts to the new political and social order.

The narrative centers on Hixar Fermi, a former Innovator and member of the Innovades, who now works as a journalist. Hixar investigates the mysterious disappearance of a space colony, Lagrange 1, which vanished without a trace. His investigation leads him to uncover a conspiracy involving the Earth Sphere Federation and remnants of the A-Laws, the former military organization that sought to maintain control through oppressive means. As Hixar delves deeper, he encounters a new faction known as the "Extend," which aims to destabilize the fragile peace by exploiting the lingering distrust between Earth and the colonies.

The story introduces new mobile suits, including the GNY-001F2 Gundam Astraea Type F2, piloted by Hixar, and the GNY-0042-874 Gundam Artemie, piloted by his ally, the enigmatic Innovade named Lichtendahl Cecile. These mobile suits play a crucial role in the escalating conflicts as Hixar and Lichtendahl work to expose the truth behind Lagrange 1's disappearance and prevent the Extend from reigniting war.

The manga also revisits themes from the original series, such as the ethical implications of armed intervention, the struggle for true peace, and the evolving relationship between humans and Innovades. Characters from the anime, including Setsuna F. Seiei and Tieria Erde, make appearances, tying the narrative to the broader "Gundam 00" timeline. The story balances political intrigue, personal struggles, and intense mobile suit battles, providing a continuation of the "Gundam 00" saga while introducing new challenges and characters.