"Kedamono Damono" is a manga series that blends elements of romance, comedy, and supernatural themes. The narrative centers around a young woman named Chizuko, who works as a caretaker at a zoo. Her life takes an unexpected turn when she encounters a mysterious man named Azusa, who possesses the ability to transform into a wolf. This transformation is tied to a curse, and Azusa seeks Chizuko's help to break it. The story explores their evolving relationship as they navigate the challenges posed by Azusa's condition and the complexities of their growing bond.

Chizuko is portrayed as a compassionate and determined individual, whose dedication to animals extends to her interactions with Azusa. Azusa, on the other hand, is depicted as aloof and guarded, struggling with the duality of his human and animal nature. Their dynamic is further complicated by the presence of other characters, including Azusa's rival, Shishigami, who also harbors a curse and competes for Chizuko's attention. The interplay between these characters drives much of the narrative tension, as alliances shift and secrets are revealed.

The plot delves into themes of identity, transformation, and the boundaries between humanity and animal instinct. As Chizuko and Azusa work together to uncover the origins of the curse, they encounter various supernatural entities and confront their own fears and desires. The story balances moments of humor with emotional depth, creating a narrative that is both engaging and thought-provoking. The resolution of the curse and the development of the characters' relationships form the core of the series, offering a satisfying blend of romance and supernatural intrigue.