"Interviews with Monster Girls" is a slice-of-life manga series that explores the lives of demi-humans, or "demi," who coexist with ordinary humans in a modern society. The story is set in a world where demi-humans, such as vampires, dullahans, succubi, and snow women, are recognized as a minority group with unique traits and challenges. The narrative primarily revolves around Tetsuo Takahashi, a high school biology teacher with a deep fascination for demi-humans, and his interactions with three demi students—Hikari Takanashi, a cheerful and energetic vampire; Kyouko Machi, a shy and reserved dullahan; and Yuki Kusakabe, a quiet and introverted snow woman. Additionally, the story includes Sakie Satou, a succubus who works as a fellow teacher at the school.

Takahashi’s curiosity about demi-humans leads him to conduct informal interviews with the demi students and Satou, aiming to understand their experiences and the biological and social aspects of their existence. Through these interactions, the series delves into the daily lives of the demi characters, highlighting their struggles with their unique traits and their efforts to fit into human society. Hikari, for instance, grapples with her vampiric need for blood while maintaining her energetic and outgoing personality. Kyouko faces challenges related to her detachable head and the societal stigma surrounding dullahans. Yuki struggles with her snow woman heritage, which causes her to unintentionally lower the temperature around her, making social interactions difficult. Sakie, on the other hand, deals with the complications of her succubus nature, which makes physical contact with others perilous due to her ability to unintentionally seduce them.

The manga balances lighthearted humor with moments of introspection, portraying the demi characters’ efforts to navigate their identities and relationships. Takahashi serves as a supportive figure, offering guidance and understanding while learning from their experiences. The series also explores themes of acceptance, diversity, and the importance of empathy, as the characters work to bridge the gap between demi-humans and humans. Through its episodic structure, "Interviews with Monster Girls" provides a thoughtful and engaging exploration of the lives of its demi-human characters, blending fantasy elements with relatable human experiences.