"Mamotte! Lollipop" is a shōjo manga series that blends fantasy, romance, and comedy. The story centers on Nina Yamada, a middle school student who accidentally swallows a magical pearl called the Crystal Pearl, which is sought after by two young sorcerer apprentices, Zero and Ichii. The pearl grants immense magical power, and its consumption makes Nina a target for various magical beings and sorcerers who wish to retrieve it. To protect her, Zero and Ichii are tasked with staying by her side until the pearl naturally passes through her system, a process that takes one year.

Zero is a brash, hot-headed sorcerer with a strong sense of justice, while Ichii is calm, intelligent, and often acts as the voice of reason. Despite their contrasting personalities, both are determined to fulfill their mission. As the story progresses, Nina develops feelings for Zero, creating a romantic subplot that intertwines with the overarching magical conflict. The trio faces numerous challenges, including rival sorcerers, magical creatures, and personal dilemmas, all while navigating the complexities of their growing relationships.

The narrative is episodic in nature, with each chapter often introducing new magical threats or comedic situations. The series balances lighthearted moments with more serious themes, such as loyalty, trust, and self-discovery. Supporting characters, including other sorcerers and Nina’s friends, add depth to the story and contribute to the dynamic between the main trio. The manga concludes with the resolution of the pearl’s influence and the evolution of the relationships between Nina, Zero, and Ichii, leaving their futures open to interpretation.