"Keep Your Hands Off Eizouken!" centers on three high school girls who share a passion for creating animation. Midori Asakusa, an imaginative and detail-oriented student, dreams of crafting fantastical worlds but lacks confidence in her abilities. Tsubame Mizusaki, a popular and talented model, harbors a secret desire to become an animator, despite societal expectations. Sayaka Kanamori, a pragmatic and business-minded individual, recognizes the potential in their collaboration and acts as the group’s producer, ensuring their creative endeavors stay grounded and financially viable.

The narrative unfolds as the trio forms the Eizouken club, a space where they can bring their animation ideas to life. Midori’s boundless creativity drives the group’s vision, often leading them into elaborate brainstorming sessions where she envisions intricate settings and mechanics for their projects. Tsubame’s expertise in character design and movement adds a layer of realism and artistry to their work, while Sayaka’s strategic thinking helps navigate logistical challenges, such as securing resources and managing time.

Throughout the series, the girls face various obstacles, including school regulations, budget constraints, and creative disagreements. Their journey is marked by a series of small-scale projects, each serving as a learning experience that hones their skills and strengthens their teamwork. The story emphasizes the collaborative nature of animation, highlighting the balance between artistic passion and practical execution.

The manga delves into the technical aspects of animation, offering insights into the creative process, from storyboarding and character design to sound effects and pacing. It also explores the personal growth of the characters as they confront their insecurities and aspirations. Midori learns to trust her instincts and embrace her unique perspective, Tsubame gains confidence in pursuing her passion despite external pressures, and Sayaka discovers the value of creativity beyond its monetary potential.

"Keep Your Hands Off Eizouken!" is a celebration of creativity and perseverance, capturing the challenges and triumphs of bringing imaginative ideas to life. The series provides a detailed and engaging portrayal of the animation process while maintaining a focus on the dynamics between its three protagonists.