"Daily Lives of High School Boys" is a slice-of-life comedy manga that centers on the humorous and often absurd experiences of a group of male students attending the all-boys Sanada North High School. The narrative is episodic, with no overarching plot, focusing instead on the everyday antics and misadventures of its characters. The main trio consists of Tadakuni, the relatively normal and grounded member of the group; Hidenori Tabata, the eccentric and imaginative ringleader; and Yoshitake Tanaka, the cheerful and slightly naive friend who often goes along with Tabata's schemes.

The series explores the mundane yet exaggerated aspects of high school life, blending relatable scenarios with over-the-top humor. The boys engage in activities such as creating fictional stories, pretending to be characters from video games, and navigating awkward social interactions. Their dynamic is characterized by playful banter, absurd logic, and a tendency to take simple situations to ridiculous extremes. The humor often stems from their exaggerated reactions to everyday occurrences, such as encountering girls from the neighboring all-girls school or dealing with their own overactive imaginations.

Secondary characters add depth to the narrative, including Mitsuo, Tadakuni's younger sister, who occasionally interacts with the group and provides a contrasting perspective. The series also features recurring gags and parodies of common manga and anime tropes, such as romantic misunderstandings and dramatic monologues, which are subverted for comedic effect. The setting primarily revolves around the school and its surroundings, with occasional forays into the boys' homes or local hangout spots.

The tone of the series is lighthearted and self-aware, often breaking the fourth wall or acknowledging the absurdity of its own scenarios. Despite its comedic focus, the manga occasionally touches on themes of friendship, adolescence, and the awkward transition into adulthood, though these moments are always framed within the context of humor. The episodic structure allows for a wide variety of comedic situations, ensuring that the narrative remains fresh and unpredictable throughout its run.