"Read or Die" is a manga series that blends elements of science fiction, espionage, and bibliophilic intrigue. The narrative centers on Yomiko Readman, a mild-mannered schoolteacher with an extraordinary ability to manipulate paper. Known as "The Paper," Yomiko works as a secret agent for the British Library's Special Operations Division, a covert organization tasked with protecting rare and dangerous books. Her mission intertwines with the discovery of a plot involving the resurrection of historical figures through a mysterious technology tied to ancient manuscripts.

The story begins with Yomiko being assigned to retrieve a stolen book, which leads her to uncover a larger conspiracy orchestrated by a shadowy organization called I-Jin. This group aims to revive historical geniuses, such as Beethoven and Napoleon, to reshape the world according to their vision. Yomiko is joined by a team of agents, including Nancy Makuhari, a skilled operative with a tragic past, and Drake Anderson, a seasoned field agent who serves as a mentor figure. Together, they navigate a series of high-stakes missions, battling I-Jin's agents and their resurrected historical figures.

As the plot unfolds, Yomiko's deep love for books and her unique powers become central to thwarting I-Jin's plans. The narrative explores themes of knowledge, power, and the ethical implications of manipulating history. The series also delves into Yomiko's personal struggles, including her sense of isolation and her unwavering dedication to preserving the written word. The climax involves a confrontation with I-Jin's leader, who seeks to use the ultimate book—a tome capable of rewriting reality itself—to achieve their goals.

The manga balances action-packed sequences with moments of introspection, creating a dynamic and engaging storyline. The characters are well-developed, with their motivations and relationships adding depth to the narrative. "Read or Die" stands out for its imaginative premise, blending historical intrigue with futuristic technology, and its celebration of literature as a powerful force in shaping humanity.