"Read or Die" is a science fiction anime series that blends espionage, supernatural abilities, and literary themes into a fast-paced narrative. The story centers on Yomiko Readman, a mild-mannered schoolteacher with an extraordinary ability to manipulate paper. Known as "The Paper," Yomiko works as a secret agent for the British Library's Special Operations Division, a covert organization tasked with protecting rare and dangerous books. Her mission intertwines with the emergence of a mysterious group called "I-Jin," which seeks to resurrect historical figures using fragments of their DNA preserved in books. These resurrected individuals, known as "Clone I-Jin," possess the knowledge and skills of their original counterparts and aim to reshape the world according to their vision.

The plot unfolds as Yomiko teams up with her colleagues, including Nancy Makuhari, a skilled operative with a tragic past, and Drake Anderson, the pragmatic leader of the Special Operations Division. Together, they investigate the I-Jin's activities, which escalate into a global threat as the resurrected figures begin to manipulate world events. The narrative explores themes of identity, the power of knowledge, and the ethical implications of cloning and resurrection. Yomiko's deep connection to books and her unwavering belief in their importance drive her actions, even as she confronts the moral dilemmas posed by the I-Jin's ambitions.

The series is structured into both episodic and overarching storylines, balancing action-packed sequences with moments of character development. Yomiko's interactions with her teammates and adversaries reveal her vulnerabilities and strengths, while the I-Jin's motivations add complexity to the conflict. The anime's climax involves a high-stakes confrontation between the British Library and the I-Jin, culminating in a resolution that underscores the enduring value of literature and human connection. Through its unique premise and dynamic characters, "Read or Die" offers a compelling exploration of the intersection between science, history, and the written word.