Brigitte Guedj is a French actress, primarily known for her extensive work in dubbing for animated series, films, and video games, as well as her career in theater. Her involvement in the performing arts began after a chance observation of a class, which led her to train with prominent coaches such as Jacqueline Duc, at the Charles Dullin school, and in workshops with Daniel Mesguish. Her career encompasses voice acting, voice direction, and stage performance.

Guedj is particularly active in the dubbing of Japanese anime, lending her voice to a wide array of characters. Among her notable roles are Carmen Rodríguez in the film Nasu: Summer in Andalusia, the wife of protagonist Pepe Benengeli's brother. She also voiced the character Promethium, the queen of the planet La Métal and mother of Maetel, in the series Space Symphony Maetel ~Ginga Tetsudō 999 Gaiden~. Her other significant anime voice roles include the titular character Doraemon in the 1979 series, Neon and Faitan in the 1999 version of Hunter × Hunter, Motoko Minagawa in Fruits Basket, Triela in Gunslinger Girl, Haruka Suzushiro in My-Hime, and Kanzenon in Saiyuki and Saiyuki Reload. She also provided voices for various characters in series such as Excel Saga, Final Fantasy: Unlimited, and Master Keaton.

In addition to her on-screen voice work, Guedj has made substantial contributions to the video game industry, both as a voice actress and a voice director. She is known for voicing the fairy Betilla in several educational Rayman games in the 1990s and later served as the voice director for Rayman Maternelle, Rayman CP, and Rayman Premiers Clics. Her extensive directing credits encompass a wide range of major titles, including The Curse of Monkey Island, StarCraft, Star Wars: Force Commander, Prince of Persia: The Sands of Time, Heroes of Might and Magic V, The Last of Us, Ratchet & Clank: Nexus, Dead Rising 3, and LittleBigPlanet 3. She also took on the role of voice director for the animated series Les Lapins Crétins: Invasion, in which she also voiced several human characters.

Beyond animation and video games, Guedj's voice can be heard in live-action series, where she dubbed Marie Schrader in the later seasons of Breaking Bad and contributed to the French versions of Grey's Anatomy and Gilmore Girls. Her career also remains deeply connected to the stage, with numerous theater credits. She has performed in plays such as Le Hasard merveilleux, a monologue written for her by Jean-Christophe Dollé, L'Invention de nos vies, and an adaptation of Le Malade imaginaire. She also conceived and performed in a musical tribute to Boris Vian titled Et Vian dans les dents.