Ayumi Mano is a Japanese voice actress born on April 24th in Saitama Prefecture. She is affiliated with the talent agency Stay Luck. Her journey into voice acting was inspired by childhood viewings of anime such as Sailor Moon and The Melancholy of Haruhi Suzumiya. Before entering the industry, she was a member of her junior high school's volleyball club and later attended dance school in high school, where she learned hip-hop. She subsequently graduated from the Osaka Amusement Media Academy to pursue her career.

Mano became a student at Stay Luck in 2015 and officially joined the agency in 2016, marking the start of her professional voice acting career. Her early roles included minor parts in series like Magi: Adventure of Sinbad, but she quickly gained recognition for her versatility.

She has built an impressive portfolio of anime roles, often voicing characters with distinct personalities. Among her most prominent and recurring roles is Natsumi in the Date A Live franchise, appearing in Date A Live III, IV, and V. She is also well-known for her portrayal of the fortune-teller Cassandra Illion in the Is It Wrong to Try to Pick Up Girls in a Dungeon? series, reprising the role across its second, third, and fourth seasons. In a leading role, she voices Alice Lendrott in The Duke of Death and His Maid.

Her other notable television anime roles include Lady Isabel Neville in Requiem of the Rose King, Fangmei in Shenmue the Animation, Esaka-san in My Sister, My Writer, Yui in Back Street Girls: Gokudols, Anastasia in Isekai Cheat Magician, Amiru Sumeragi in Blue Reflection Ray, Dr. Tamago in Wixoss Diva(A)Live, Hiromi Hishigata in A Certain Scientific Accelerator, Kaede Akana in Mewkledreamy, Iwazaru in Last Period: the journey to the end of the despair, and Bridget Page in Sugar Apple Fairy Tale. She has also had recurring roles in long-running series such as Black Clover and Demon Slayer: Kimetsu no Yaiba.

Beyond anime, Mano is active in video games, lending her voice to characters in major titles. Some of her game roles include Yoshimi Ibaragi in Blue Archive, Hamel in Path to Nowhere, and characters in Azur Lane and 13 Sentinels: Aegis Rim. She has also contributed to the dubbed version of foreign films, such as the 2017 film Deep.

A notable aspect of Mano's career is her recurring collaboration with the works she is cast in, particularly demonstrating her musical talent. For her leading role in The Duke of Death and His Maid, she performed multiple theme songs and insert songs across its three seasons. She was also part of the unit Wiseman, which performed the ending theme for Last Period: the journey to the end of the despair. In addition to her voice work, she holds a beautician's license and a driver's license. She is also a passionate fan of the Tokyo Yakult Swallows baseball team, a hobby that led to her throwing the ceremonial first pitch at their 2025 home opening game.