Simon Isaacson is an American voice actor known for his extensive work in English-language dubs of anime and video games, primarily during the 1990s and 2000s. He is also known professionally by his birth name, Simon Prescott, and occasionally by other aliases such as Ben Isaacson or Sy Prescott. He was born on May 26, 1936, in Brooklyn, New York.

Isaacson's career encompasses a wide range of roles in animated series, films, and video games. He is particularly recognized for his contributions to the Gundam franchise. He voiced the patriarch Degwin Sodo Zabi, the Sovereign of the Principality of Zeon, in the English adaptation of the Mobile Suit Gundam movie trilogy. His other significant roles in the Gundam universe include Captain Eiphar Synapse in Mobile Suit Gundam 0083: Stardust Memory and Meitzer Ronah in Mobile Suit Gundam F91.

Beyond Gundam, Isaacson has portrayed numerous authoritative and elderly characters. His notable anime voice roles include Chief Nakamura in Ghost in the Shell, Dr. Laughton in Metropolis, Professor Isaac Gilmore in Cyborg 009: The Cyborg Soldier, and Aritomo Yamagata in Rurouni Kenshin. He also provided voices for the Animaze dub of Akira as The Doctor, as well as roles in Cowboy Bebop, Outlaw Star, Samurai Champloo, and various installments of the Street Fighter Alpha series.

Throughout his career, Isaacson was a prolific presence in the anime dubbing industry, frequently collaborating with other prominent voice actors and studios based in Los Angeles. His work displays recurring collaborations with voice actors such as Steve Blum, Kirk Thornton, and Richard Cansino across numerous projects. In addition to his voice work, his filmography includes appearances in live-action television series and roles in video games such as The Bouncer and Total Overdose: A Gunslinger's Tale in Mexico.