Kaeko Sakamoto is primarily known as a casting director and producer for English-language dubs of anime, but she has also worked as a voice actor. She is closely associated with Bang Zoom! Entertainment, a prominent audio production company based in Burbank, California, where she holds a key position as a casting director.

Sakamoto is best known for providing the English voice of Mokona, a small, white, rabbit-like creature, in the anime series Magic Knight Rayearth. She voiced this character in both the original 1994 television series and its second season, Magic Knight Rayearth 2, contributing to the English dub produced by Bang Zoom! Entertainment. Her performance as Mokona, a creature that primarily communicates with the expression "puu," remains her most recognized voice acting credit.

Beyond her work as a performer, Sakamoto has achieved significant recognition for her work behind the scenes. In 2008, she was named Best Casting Director by the Society for the Promotion of Japanese Animation (SPJA) for her work on the English dub of the popular series The Melancholy of Haruhi Suzumiya. The award was presented at that year's Anime Expo convention. This role involved assembling a notable cast of voice actors for the North American release of the series.

Her career reflects a substantial contribution to the anime industry, not primarily as a voice actor, but as a casting professional who has helped shape numerous English-language adaptations. Her work on The Melancholy of Haruhi Suzumiya is a particularly notable achievement in her career.