William H. Macy, an acclaimed American actor known for his work in film and television, has ventured into the world of voice acting for animated features, including projects that fall within the anime genre. His most prominent and widely recognized anime voice role is that of Mr. Satomi in the English-language dub of the 2013 Studio Ghibli film The Wind Rises, directed by Hayao Miyazaki. In this historical drama, Macy voices the father of the female lead, Nahoko Satomi, a role he described as that of a conflicted father who wants the best for his ill daughter.

Beyond this major anime film, Macy has an extensive body of voice work in Western animation and other media. His voice acting credits include the role of the Head Dentist in the 2012 French-Belgian animated film Ernest & Celestine, which received an Academy Award nomination for Best Animated Feature. Earlier in his career, he provided the voice for the character Brian in the 2006 animated film The Dog Who Saved the Holidays (also known as Doogal) and had a role in the animated series The Lionhearts, where he voiced Leo the MGM lion. His other voice credits include appearances in animated television series such as Batman Beyond, Superman: The Animated Series, and King of the Hill.

While Macy has voiced characters in various animated projects, his direct involvement in Japanese anime remains primarily defined by his work on The Wind Rises, a significant contribution to the medium as part of the English dub cast for a celebrated film by a renowned director.