"Comical Psychosomatic Medicine" is a short-form anime series that blends comedy with educational elements, focusing on mental health and psychological concepts. The narrative revolves around a young woman named Anna, who visits a quirky psychiatrist named Dr. Akagi to address her struggles with stress and anxiety. Each episode explores a different psychological condition or mental health issue, such as depression, insomnia, or social anxiety, using humor and exaggerated scenarios to make the topics accessible and engaging.

Dr. Akagi, the eccentric psychiatrist, employs unconventional and often absurd methods to explain and treat Anna's conditions. His explanations are accompanied by visual gags and comedic interactions, which serve to demystify complex psychological concepts. Anna, as the patient, represents the audience's perspective, reacting with confusion, frustration, or amusement to Dr. Akagi's antics. The dynamic between the two characters drives the series, with Anna's relatable struggles contrasting with Dr. Akagi's over-the-top personality.

The series is structured as a series of vignettes, with each episode tackling a specific mental health topic. The humor is often derived from the absurdity of Dr. Akagi's explanations, which include bizarre analogies, exaggerated physical comedy, and surreal visual metaphors. Despite the comedic tone, the series maintains an underlying educational purpose, aiming to raise awareness about mental health issues in a lighthearted and approachable manner.

Supporting characters occasionally appear to provide additional perspectives or comedic relief, but the focus remains primarily on Anna and Dr. Akagi. The episodic format ensures that each topic is self-contained, making the series easy to follow while still maintaining a cohesive narrative thread through the recurring interactions between the two main characters. The blend of comedy and education creates a unique viewing experience, offering both entertainment and insight into psychological well-being.