"Eguchi Hisashi no Nantoka Naru Desho!" is a comedic anime series that revolves around the daily life and misadventures of Eguchi Hisashi, a quirky and eccentric individual whose unconventional behavior often leads to humorous and unpredictable situations. The narrative is episodic, with each episode presenting a self-contained story that highlights Eguchi's peculiar interactions with those around him, including his family, friends, and acquaintances.

Eguchi is characterized by his offbeat personality and tendency to approach ordinary situations in bizarre ways. His actions frequently result in chaos, misunderstandings, and comedic outcomes, often leaving those around him bewildered or exasperated. Despite his oddities, Eguchi's intentions are generally well-meaning, though his methods are anything but conventional. The series thrives on the contrast between Eguchi's unconventional mindset and the more grounded perspectives of the people in his life.

The supporting cast includes a range of characters who serve as foils to Eguchi's eccentricity. These include his long-suffering wife, who often finds herself caught up in his schemes, and his friends, who are alternately amused and frustrated by his antics. The interactions between Eguchi and these characters drive much of the humor, as they navigate the absurdity he brings into their lives.

The humor in "Eguchi Hisashi no Nantoka Naru Desho!" is largely situational, relying on the absurdity of Eguchi's actions and the reactions they provoke. The series does not follow a continuous plot but instead focuses on delivering comedic vignettes that showcase Eguchi's unique worldview. The tone is lighthearted, with an emphasis on slapstick and wordplay, making it accessible to a broad audience.

Overall, the series is a comedic exploration of individuality and the chaos that can arise when one person's eccentricities collide with the expectations of society. Its episodic structure and focus on humor make it a straightforward yet entertaining watch, centered around the antics of its unconventional protagonist.