In a certain house lives a certain older sister and her cat, Nya, a small-time streamer who finds herself unable to sleep at night despite being a nocturnal creature, as she constantly frets over the performance metrics of her video uploads. She is not alone in the digital jungle. Her world includes Tomoneko, a popular channel cat who understands that long-term success depends entirely on possessing an excellent personality, and Tsuyoneko, a martial arts channel cat whose physical prowess is such that he can defeat stray dogs. The series follows the everyday lives of these three feline online content creators as they navigate the pressures and absurdities of social media society.

The narrative primarily unfolds in and around their shared household, a space that becomes a stage for the anxieties and triumphs of digital-age validation. Nya’s journey is defined by her volatile relationship with viewer feedback, where a single comment can send her spirits soaring or crashing down. The series balances the mundane realities of running a small channel with increasingly unexpected turns, including the introduction of a powerful rival cat named Momochi, voiced by Akio Ōtsuka, who also serves as the series narrator. This rivalry culminates in episode fourteen, titled The Battle Across Time and Space, where the story takes a turn toward the surreal and the conflict approaches a deeper mystery.

Notable arcs include a Christmas special, YouTuNya: Christmas tte Mita, in which Nya plans to spend a fun holiday with her sister but forgets something crucial that causes chaos for Santa Claus and his reindeer. The series features a distinct voice cast, with Nya brought to life by Fairouz Ai, Tomoneko by Yūki Kaji, and Tsuyoneko by Subaru Kimura.