"Sennin Buraku" is a comedic anime series that revolves around the daily lives of the eccentric residents of a secluded mountain village. The village, known as Sennin Buraku, is home to a group of individuals who have chosen to live away from modern society, each with their own quirks and unique personalities. The narrative primarily focuses on their interactions, misadventures, and the humorous situations that arise from their unconventional lifestyles.

The central character is a young man named Tanaka, who moves to Sennin Buraku seeking a simpler life. Tanaka quickly becomes entangled in the village's peculiar dynamics, often finding himself at the center of the villagers' antics. Among the residents is the village chief, an elderly man with a penchant for storytelling and a mysterious past. Another key figure is Hanako, a spirited and resourceful woman who often takes charge of resolving conflicts and organizing village events. There is also a reclusive inventor who creates bizarre gadgets, adding an element of unpredictability to the story.

The plot unfolds through a series of episodic vignettes, each highlighting different aspects of village life. Themes of community, self-sufficiency, and the clash between traditional and modern values are explored through the characters' experiences. The villagers frequently face challenges such as natural disasters, external threats, and internal disputes, but their strong sense of camaraderie and shared history help them overcome these obstacles.

Humor is a central element, derived from the characters' exaggerated traits and the absurdity of their situations. The series balances its comedic tone with moments of warmth and introspection, offering a nuanced portrayal of life in Sennin Buraku. The narrative does not follow a linear progression but instead provides a slice-of-life perspective, allowing viewers to immerse themselves in the village's unique culture and the relationships between its inhabitants.