"Vampire Holmes" is a short-form anime series centered around Holmes, a vampire detective with a peculiar personality and a penchant for solving supernatural mysteries. Despite his eccentric and often lazy demeanor, Holmes possesses sharp deductive skills and a deep understanding of the occult. He resides in a rundown mansion in London, where he spends most of his time lounging and avoiding work. His companion, Hart, is a young man who serves as his assistant and often finds himself exasperated by Holmes's antics. Hart is more grounded and practical, providing a counterbalance to Holmes's erratic behavior.

The narrative unfolds through episodic cases involving supernatural phenomena, often tied to vampires, ghosts, or other mythical creatures. Holmes and Hart investigate these occurrences, with Holmes relying on his vast knowledge of the supernatural and his unique abilities as a vampire. The cases range from comedic to mildly suspenseful, with Holmes frequently solving mysteries through unconventional methods. The series maintains a lighthearted tone, blending elements of mystery, comedy, and the supernatural.

Holmes's character is defined by his laid-back attitude, sharp wit, and occasional displays of brilliance, while Hart serves as the straight man, often questioning Holmes's methods but ultimately supporting him. The dynamic between the two characters drives much of the series' humor and charm. The anime does not delve deeply into overarching plotlines, instead focusing on self-contained episodes that highlight the duo's investigative adventures. The setting, a gothic yet whimsical version of London, adds to the series' atmosphere, blending the mundane with the supernatural.

Overall, "Vampire Holmes" offers a quirky take on the detective genre, combining supernatural elements with comedic storytelling and a distinctive protagonist. The series is characterized by its brevity, episodic structure, and the interplay between its two main characters, making it a light and entertaining watch for fans of supernatural mysteries.