"Oruchuban Ebichu" is a short-form anime series adapted from the manga by Risa Itō. The story revolves around Ebichu, a hyper-energetic and anthropomorphic hamster who serves as the loyal housekeeper for her owner, a 25-year-old office lady referred to as "Office Lady" or "OL." Despite her best intentions, Ebichu's overzealous and often inappropriate behavior frequently leads to chaotic and comedic situations. The series is structured in episodic vignettes, with each episode running approximately eight minutes.

Ebichu's daily tasks include cleaning, cooking, and offering unsolicited advice to her owner, who is often preoccupied with her mundane and sometimes frustrating life. The Office Lady is depicted as a somewhat lazy and indecisive individual, frequently struggling with her romantic relationship with her boyfriend, referred to as "Maa-kun." Maa-kun is portrayed as selfish and manipulative, often exploiting the Office Lady's affection for his own benefit. Ebichu, despite her loyalty, often finds herself caught in the middle of their dysfunctional relationship, leading to absurd and risqué humor.

The humor in "Oruchuban Ebichu" is characterized by its adult themes, including sexual innuendo, slapstick comedy, and satirical commentary on modern relationships. Ebichu's naivety and boundless enthusiasm contrast sharply with the more cynical and flawed human characters, creating a dynamic that drives much of the comedy. The series also features recurring side characters, such as Ebichu's rival, Kaoru, another hamster who often competes with Ebichu for attention and affection.

The narrative structure is light and episodic, with no overarching plot, focusing instead on the daily interactions and misadventures of Ebichu and her owner. The series balances its comedic tone with moments of absurdity and occasional heartwarming scenes, though the primary emphasis remains on humor and satire. The characters' exaggerated personalities and the show's willingness to push boundaries with its content make it a distinctive entry in the comedy genre.