"Ore, Tsushima" centers on Tsushima, a high school student who struggles with social interactions and self-esteem. The narrative explores his daily life as he navigates the challenges of adolescence, often finding himself in awkward or humorous situations. Tsushima's introverted nature contrasts sharply with the vibrant personalities of his classmates, creating a dynamic that drives much of the series' comedic and emotional moments.

The plot unfolds through a series of episodic events, each highlighting Tsushima's attempts to connect with others while grappling with his insecurities. His interactions with classmates, such as the outgoing and confident Yuki and the quiet but observant Aoi, reveal different facets of his personality. Yuki often pushes Tsushima out of his comfort zone, while Aoi provides a more understanding and supportive presence. These relationships gradually help Tsushima grow, though his progress is marked by setbacks and moments of self-doubt.

A recurring theme is Tsushima's internal struggle to reconcile his desire for acceptance with his fear of rejection. This tension is explored through his participation in school activities, such as joining a club or working on group projects, where his awkwardness often leads to comedic misunderstandings. Despite these challenges, Tsushima's determination to improve himself and his relationships forms the emotional core of the series.

The anime balances humor with moments of introspection, using Tsushima's experiences to reflect on broader themes of self-discovery and the complexities of human connection. The supporting cast, including teachers and family members, adds depth to the narrative, providing additional perspectives on Tsushima's journey. Through its blend of comedy and heartfelt storytelling, "Ore, Tsushima" offers a relatable portrayal of the struggles and triumphs of adolescence.