"22/7" is an anime and manga series centered around a group of young girls who are brought together to form an idol group under the guidance of a mysterious organization known as "The Wall." The narrative begins with the protagonist, Miu Takigawa, a reserved and introverted high school student, receiving a letter instructing her to attend an audition. Alongside seven other girls—Sakura Fujima, Reika Satō, Nicole Saitō, Ayaka Tachikawa, Jun Toda, Miyako Kōno, and Chiyoko Sonoda—Miu is selected to become part of the idol group "22/7."

The story unfolds as the girls navigate the challenges of balancing their personal lives with the demands of their new careers as idols. Each character has a distinct personality and background, which are gradually revealed through their interactions and individual story arcs. Miu, for instance, struggles with her self-confidence and fear of failure, while Sakura, the group's cheerful and optimistic leader, often acts as a unifying force. Reika, a perfectionist with a strong sense of responsibility, contrasts with Nicole, who is carefree and often clashes with the group's rules. Ayaka, a former child actress, grapples with the pressures of fame, while Jun, a quiet and reserved girl, finds it difficult to express herself. Miyako, the youngest member, brings a playful and energetic dynamic, and Chiyoko, the oldest, often provides a mature and grounded perspective.

The overarching narrative is driven by the enigmatic directives of "The Wall," which issues cryptic instructions to the group, often pushing them out of their comfort zones. These instructions serve as catalysts for character development, forcing the girls to confront their fears, insecurities, and past traumas. As the story progresses, the group faces various challenges, including internal conflicts, public scrutiny, and the pressures of the entertainment industry. Despite these obstacles, they gradually grow closer, learning to rely on each other and work as a cohesive unit.

The series also delves into the personal lives of the characters, exploring their relationships with family, friends, and each other. Themes of identity, self-discovery, and the pursuit of dreams are central to the narrative, as each girl strives to find her place within the group and the world at large. The interplay between their individual struggles and their collective journey as idols creates a compelling and emotionally resonant story.

"22/7" combines elements of slice-of-life, drama, and music, with the girls' performances as idols serving as both a narrative device and a reflection of their growth. The series is notable for its focus on character development and its exploration of the complexities of human emotions, making it a distinctive entry in the idol genre.