"Alice Tanteikyoku" is a mystery and psychological thriller anime series that revolves around a young girl named Alice Arisugawa, who possesses an extraordinary ability to solve crimes. Alice is a highly intelligent and observant individual, often described as a "human lie detector" due to her uncanny ability to discern truth from deception. She uses her skills to assist the police in solving complex cases, often delving into the darkest corners of human behavior and uncovering hidden truths.

The narrative is structured around episodic cases, each presenting a unique mystery that Alice must unravel. These cases range from seemingly mundane incidents to high-stakes criminal investigations, often involving murder, theft, and other serious crimes. Alice's approach to solving these mysteries is methodical and analytical, relying on her keen intellect and attention to detail rather than physical prowess. Her ability to read people and situations with precision makes her an invaluable asset to the police force, though it also isolates her from her peers due to her perceived coldness and detachment.

Supporting characters include Kenzou Asaba, a police officer who frequently collaborates with Alice. Asaba serves as a foil to Alice, providing a more emotional and empathetic perspective on the cases they investigate. Their dynamic is central to the series, as Asaba's humanistic approach often contrasts with Alice's clinical detachment, creating a balance that drives the narrative forward. Other recurring characters include various members of the police force and individuals connected to the cases, each contributing to the intricate web of mysteries that Alice must navigate.

The series explores themes of truth, justice, and the nature of human morality, often challenging the audience to question their own perceptions of right and wrong. The psychological depth of the characters and the complexity of the cases make "Alice Tanteikyoku" a compelling exploration of the human condition, set against the backdrop of a crime-ridden world. The narrative's focus on intellectual problem-solving and moral ambiguity sets it apart from more action-oriented mystery series, offering a thought-provoking and engaging viewing experience.