"Nekota no Koto ga Ki ni Natte Shikatanai" centers on the life of Nekota, a young man who unexpectedly begins to exhibit cat-like behaviors after a mysterious encounter. The series explores his daily struggles as he navigates the challenges of his newfound feline traits, which include heightened senses, agility, and an inexplicable attraction to catnip. These changes disrupt his ordinary life, affecting his relationships, work, and self-identity.

The narrative delves into Nekota's interactions with those around him, particularly his childhood friend, Ayaka, who becomes a key figure in helping him adapt to his condition. Ayaka’s pragmatic and supportive nature contrasts with Nekota’s growing confusion and frustration, creating a dynamic that drives much of the story’s emotional core. Other characters, such as Nekota’s coworkers and a quirky veterinarian, provide additional layers to the plot, offering both comedic relief and moments of insight into Nekota’s predicament.

As the series progresses, Nekota’s condition becomes more complex, leading to a deeper exploration of its origins. The story introduces elements of mystery and fantasy, hinting at supernatural forces or scientific anomalies that may have triggered his transformation. This blend of slice-of-life storytelling with speculative elements creates a unique narrative structure, balancing humor, drama, and intrigue. The series ultimately examines themes of identity, adaptation, and the human-animal connection, all while maintaining a lighthearted yet thought-provoking tone.