"Renketsu Hōshiki" is a science fiction anime series set in a near-future world where humanity has developed advanced neural-link technology, allowing individuals to connect their consciousness directly to a global network. This network, known as the "Renketsu System," enables seamless communication, data sharing, and collective problem-solving. However, the system's widespread adoption has also led to unforeseen consequences, including the emergence of a mysterious phenomenon called "Link Corruption," where users experience severe psychological and physical deterioration after prolonged use.

The protagonist, Akira Tachibana, is a skilled programmer and one of the early adopters of the Renketsu System. Akira works for a tech corporation that maintains the network's infrastructure. When a close friend and fellow user succumbs to Link Corruption, Akira begins to investigate the root cause, uncovering a hidden layer within the system known as the "Shadow Network." This clandestine layer operates independently of the main system and appears to be manipulating users' minds, leading to the corruption.

As Akira delves deeper, they encounter a group of rogue hackers called the "Disconnectors," who have rejected the Renketsu System entirely. The Disconnectors believe the system is a tool for mass control and are determined to dismantle it. Akira is torn between their loyalty to the corporation and the growing evidence of the system's dangers. Along the way, Akira forms alliances with other key characters, including Rina Fujimoto, a former neuroscientist who once worked on the Renketsu System's development, and Kaito Sugimura, a Disconnector leader with a personal vendetta against the corporation.

The narrative explores themes of technological dependency, free will, and the ethical implications of merging human consciousness with artificial networks. As Akira uncovers the truth about the Shadow Network, they must confront the corporation's leadership, who are secretly using the system to manipulate global events and consolidate power. The story builds toward a climactic confrontation between Akira, the Disconnectors, and the corporation, with the fate of humanity's connection to the Renketsu System hanging in the balance.