"Elf Hime Nina" centers on Nina, a young elf princess from the magical realm of Elfuland, who is transported to the human world after her kingdom is attacked by the demon lord Zaus. In the human world, she encounters Takuto, a kind-hearted boy who becomes her protector and guide. The series explores Nina's efforts to adapt to human life while searching for a way to return to her homeland and reclaim her throne. Along the way, she forms bonds with Takuto and his friends, who assist her in battling Zaus's minions and uncovering the truth behind the demon lord's invasion.

The narrative intertwines elements of fantasy, adventure, and comedy, as Nina's naivety about human customs often leads to humorous situations. However, the tone shifts during moments of conflict, particularly when Zaus's forces attempt to capture Nina to prevent her from fulfilling her destiny. The story delves into themes of friendship, courage, and the clash between magical and human worlds, as Nina learns to harness her latent magical abilities and grow into her role as a leader.

Key characters include Nina, whose innocence and determination drive the plot; Takuto, whose loyalty and resourcefulness make him a reliable ally; and Zaus, the primary antagonist whose motives and connection to Elfuland are gradually revealed. The series balances episodic adventures with an overarching plot, culminating in a climactic confrontation that tests Nina's resolve and the strength of her newfound friendships.