"Seito Shokun!" is a school drama anime set in the prestigious Seiran Academy, a private all-girls school in Japan. The story revolves around the students and faculty as they navigate the complexities of adolescence, societal expectations, and personal growth. The central figure is Yumi Ayuhara, a bright and idealistic student who becomes the class representative. Yumi is determined to uphold the school's traditions while addressing the challenges faced by her peers, often clashing with the rigid administration and conservative values of the institution.

The narrative explores various themes such as friendship, leadership, and the struggle for individuality within a structured environment. Yumi's journey is marked by her efforts to mediate conflicts among her classmates, including the rebellious and outspoken Reiko Naitou, who challenges the school's outdated rules and norms. Another key character is the reserved and introspective Shizuko Fujiki, whose quiet demeanor hides a deep sense of responsibility and loyalty to her friends. The faculty, particularly the strict headmistress and the progressive young teacher Ms. Sakamoto, play significant roles in shaping the students' experiences, often representing the tension between tradition and modernity.

The plot unfolds through a series of episodic arcs, each focusing on different students and their personal struggles. These include issues such as academic pressure, family expectations, romantic relationships, and the search for self-identity. The series also delves into broader societal issues, such as gender roles and the impact of cultural norms on young women. Through these stories, "Seito Shokun!" portrays the challenges of adolescence with a mix of drama, humor, and heartfelt moments, offering a nuanced depiction of life in a high school setting. The interactions between the characters drive the narrative, highlighting their growth and the evolving dynamics within the school community.