Nene Yashiro is a sixteen-year-old first-year high school student at Kamome Academy and the main female protagonist of the story. She is an outgoing and earnest girl who deeply desires the approval of her peers and is generally kind to others, sometimes to the point of naivety. Her cheerful and friendly demeanor is balanced by a genuine sense of empathy, as she often shows concern for the feelings of those around her. Nene is also notably obsessed with charms and talismans, frequently declaring her wish to make friends with everyone.

Her involvement with the supernatural begins when she attempts to summon the spirit known as Hanako-kun, the seventh mystery of Kamome Academy, in search of a romantic wish. After consuming a mermaid scale that ties their fates together, she becomes Hanako-kun’s human assistant, tasked with cleaning the bathroom he haunts in exchange for his help. This role places her at the center of the school’s occult secrets and conflicts with the other mysteries. Nene is naturally able to see spirits, a trait later revealed to be linked to her shortened lifespan—she has only about a year left to live because of her proximity to the Far Shore.

Her primary motivation throughout the series is to build lasting friendships and help those in need, which often leads her into dangerous situations with supernatural entities. As she navigates the mysteries of Kamome Academy, Nene grows from a lonely girl seeking romance into a more courageous and self-aware individual, learning to confront her own fears and insecurities. Her relationship with Hanako-kun evolves from curiosity into a deep emotional bond, with Nene acting as his moral compass and grounding him with her earnest kindness. She also forms a close friendship with Aoi, her classmate, who provides normal high school support, and an alliance with Kou Minamoto, an exorcist student who becomes a crucial ally in battles against hostile apparitions.

While Nene lacks traditional combat abilities, her understanding of supernatural charms and her connection to spirits allow her to communicate and mediate between humans and the spirit world. Her inexperience with these powers sometimes leads to unintended consequences, but she remains determined to protect those she cares about. Over the course of the story, Nene’s character is marked by her loyalty, her growing bravery, and her willingness to stand by Hanako-kun even as she learns about his tragic past and the dangerous truths of their world. Her journey highlights themes of friendship, acceptance, and the courage to face one’s own fate.