Sakura Otome is a 15-year-old Second Lycoris agent at the Direct Attack Tokyo Branch, having transferred from Hokkaido to replace Takina Inoue as Fuki Harukawa’s partner. Born March 6 with blood type B, she has light brown hair styled in a two-block undercut and aubergine eyes. Her standard navy blue Lycoris uniform pairs with teal sneakers, reflecting her energetic presence.

Bold, ambitious, and lively, Sakura frequently appends "ssu" to her sentences. She openly competes to become a First Lycoris through mission successes, maintaining teasing rivalries with Chisato Nishikigi and Takina Inoue without malice. Though occasionally impulsive, she shows fierce loyalty to Fuki and expresses remorse for shortcomings, like apologizing after training defeats.

Sakura wields sharp shooting skills praised by Fuki and exhibits rapid decision-making in crises. However, predictable shooting patterns and recklessness hinder her against experienced opponents. Her quick thinking shines during the Enkuboku explosion: she identifies a suspicious cleaning robot and orders bulletproof shields deployed, reducing casualties.

Key involvements include a paint bullet training loss against Chisato and Takina in Episode 3, VR gaming with Fuki in Episode 4, and frequent LycoReco café visits in Episode 7—often attempting to order sweets before Fuki redirects her. She critically intervenes in Episode 11’s Enkuboku incident. In Episode 13, she survives injuries from Majima’s attack, later recovering while enjoying a parfait.

Sakura deeply respects partner-mentor Fuki Harukawa, acknowledges Chisato’s superior skills through friendly rivalry, and engages Takina with playful provocation as her predecessor. The light novel "Lycoris Recoil: Ordinary Days" confirms her Hokkaido origins and goal-driven work ethic. The 2025 ONA "Lycoris Recoil: Friends are thieves of time" features her in a consistent supporting role.