Chrome hails from Ishigami Village, born in the Stone World long after humanity's petrification. Independent experimentation fuels his intense fascination with natural materials and chemical reactions, earning him the local designation "sorcerer" for creating phenomena like fire color changes, misunderstood as magic. His explorations amass an extensive collection of minerals and resources, unintentionally laying a foundation for future scientific work.
He exhibits high energy, innate curiosity, and strong self-confidence in his intellectual pursuits, though his knowledge remains self-taught and fragmented before external influences. Chrome demonstrates loyalty and bravery, willingly facing physical risks during experiments or to protect others, despite lacking exceptional combat prowess compared to village warriors. His personality includes a combative streak when his self-proclaimed roles are challenged, leading him to immediately confront perceived rivals like newly arrived scientists or explorers.
Romantic matters receive little attention from him, showing consistent unawareness or disinterest in implications about his relationship with Ruri, the village priestess. He occasionally references marriage as a future consideration only after completing scientific projects, reflecting his prioritization of intellectual pursuits.
Initial encounters with Senku Ishigami provoke rivalry, as Chrome perceives another "sorcerer" encroaching on his domain. This rivalry dissolves when Senku explains science, moving Chrome to tears and compelling him to become Senku's apprentice and ally. Chrome's knowledge of local resources proves invaluable for early Kingdom of Science projects like sulfa drugs and revival fluid. He collaborates with craftsman Kaseki to independently construct inventions such as a functional water wheel without Senku's direct guidance, demonstrating adaptive problem-solving.
During the village leadership tournament, Chrome participates primarily to secure Ruri's cure rather than marital status. He employs chemical smoke screens and psychological tactics devised with Gen Asagiri to defeat physically superior opponents like Magma, leveraging his understanding of materials and human behavior.
In conflicts against the Tsukasa Empire, Chrome is captured but withstands interrogation and death threats without betraying Senku's secrets. Using nitric acid to dissolve bamboo prison bars—applying previously acquired scientific principles—he escapes. He later guides allies through enemy traps using his terrain knowledge. His actions directly enable the Kingdom of Science's victory during the Stone Wars.
Following the conflict's resolution, he earns recognition as one of the Five Wise Commanders despite being the only post-petrification human among them. He joins the Craftsmanship and Development Team, contributing to ventures like the Perseus ship construction and expeditions to Treasure Island. His later explorations beyond Japan involve confronting new adversaries and uncovering petrification mysteries. He demonstrates strategic ingenuity, such as proposing mass temporary petrification to neutralize threats non-lethally.
Chrome possesses notable endurance for long-distance running, though his physical combat abilities remain average. Intellectually, he recreates historical inventions like drills and metal detectors through independent experimentation, later comprehending complex concepts like telephone sound transmission with minimal explanation. His expertise in mineralogy and resource location persists as a critical asset throughout scientific endeavors, with even modern-era characters eventually acknowledging his scientific acumen during advanced projects like space exploration preparations.
His relationship with Senku evolves from apprentice to trusted partner, collaborating on anti-petrification strategies and global missions against the Why-Man entity. Persistent failed attempts to confess to Ruri culminate in a marriage proposal during post-canon events, as documented in spin-off media.