Megumi Amano, a hybrid from the *Urotsukidōji* series, serves as the sister of Jyaku Amano, a man-beast guardian charged with protecting the prophesied Overfiend. Her characterization shifts starkly across mediums. The manga frames her as a cunning antagonist who exploits seduction to entrap men, either framing them for rape or devouring them in her monstrous form. Her vendetta against Akemi Itō ignites when Tatsuo Nagumo, the Overfiend’s human host, spurns her advances, driving her to summon a sea demon in a failed attempt to destroy Akemi. The anime reimagines her with nuanced humanity, stripping away her malice to highlight empathy and loyalty. Here, she aids Jyaku in shielding Nagumo and Akemi from demonic threats while navigating a tragic romance with Takeaki Kiryū, Nagumo’s cousin. Their relationship culminates in her killing him during a clash with the antagonist Münchhausen II, exposing her struggle between duty and emotional ties. In *Urotsukidōji III: Return of the Overfiend*, Megumi’s arc continues the anime’s trajectory, collaborating with Jyaku to secure the survival of the prematurely born Overfiend. The plot thrusts her into resistance against the despotic Caesar and survival within a demon-infested post-apocalypse, underscoring her adaptability amid chaos spurred by the Overfiend’s resurgence and hybrid demon beasts. Her core background remains unchanged, with no expanded development documented beyond the primary manga and anime narratives.