"We Never Learn" centers around Nariyuki Yuiga, a hardworking and academically gifted high school student from a financially struggling family. Due to his exceptional grades, Nariyuki is offered a prestigious college recommendation, but on the condition that he tutors two of his classmates, Rizu Ogata and Fumino Furuhashi, in their weakest subjects. Rizu is a genius in mathematics and science but struggles with literature and humanities, while Fumino excels in literature and humanities but fails to grasp mathematics and science. Despite their brilliance in their respective fields, their inability to improve in their weaker subjects threatens their future academic prospects.

As the story progresses, Nariyuki’s tutoring responsibilities expand to include other classmates, each with their own unique academic challenges and personal aspirations. Uruka Takemoto, a talented swimmer aiming for a sports scholarship, struggles with English. Asumi Kominami, a part-time cram school teacher, hides her academic insecurities behind a confident facade. Mafuyu Kirisu, their strict and disciplined homeroom teacher, secretly harbors her own struggles with teaching and personal growth. The narrative explores the dynamics between Nariyuki and these characters as they navigate their academic goals, personal dreams, and evolving relationships.

The series balances comedic and heartfelt moments, often highlighting the characters' determination to overcome their weaknesses and support one another. Nariyuki’s role as a tutor becomes a catalyst for personal growth, not only for his classmates but also for himself, as he learns to balance his own ambitions with the challenges of helping others. The story delves into themes of perseverance, self-discovery, and the importance of mutual support, all while maintaining a lighthearted and engaging tone. The characters’ interactions and individual arcs contribute to a narrative that emphasizes the value of hard work and the pursuit of one’s dreams, regardless of the obstacles faced.