"A Strange and Mystifying Story" is a supernatural manga series that blends elements of folklore, romance, and mystery. The narrative centers on Tsuzuki, a young man who becomes entangled with a mysterious entity known as Asato Iwashima. Asato is a powerful being with a connection to ancient Japanese mythology, and his presence in Tsuzuki's life marks the beginning of a series of supernatural events. The story explores their evolving relationship, which is fraught with tension, as Asato's intentions remain ambiguous and his powers pose a constant threat to Tsuzuki's safety.

The plot unfolds in a modern setting but is deeply rooted in traditional Japanese folklore, with yokai and other supernatural entities playing significant roles. Tsuzuki, initially an ordinary individual, is drawn into a world where the boundaries between the human and spiritual realms blur. Asato, who appears human but harbors immense power, becomes both a protector and a source of danger for Tsuzuki. Their dynamic is complicated by Asato's enigmatic nature and his connection to a tragic past that gradually comes to light.

Secondary characters, including other supernatural beings and humans caught in the crossfire, add depth to the narrative. These characters often serve as catalysts for key events, revealing more about the world's mythology and the central relationship between Tsuzuki and Asato. Themes of trust, sacrifice, and the consequences of wielding power are explored as the story progresses, with the stakes escalating as darker forces emerge.

The manga balances episodic supernatural encounters with an overarching plot that delves into Asato's origins and his ties to Tsuzuki. The pacing allows for both action-driven sequences and quieter, introspective moments that develop the characters' emotional arcs. The interplay between the mundane and the mystical creates a compelling contrast, grounding the fantastical elements in relatable human experiences. The series maintains a consistent focus on the central relationship, using it as a lens to explore broader themes of identity, loyalty, and the coexistence of humans and spirits.