"Domin-8 Me!" is a manga series that blends elements of supernatural horror, psychological drama, and dark fantasy. The narrative centers around a young man named Kaito, who becomes entangled in a nightmarish scenario after encountering a mysterious woman named Lilith. Lilith, a seductive and enigmatic figure, possesses supernatural powers and marks Kaito with a curse that binds him to her will. This curse grants Kaito immense strength and regenerative abilities but at a cost: he must obey Lilith's commands or face excruciating pain and potential death.

As the story progresses, Kaito learns that Lilith is one of several powerful entities known as "Dominators," who manipulate and enslave humans to fulfill their own desires. These Dominators are engaged in a secret war, using their thralls as pawns in their battles for dominance. Kaito, now a thrall, struggles to retain his autonomy while navigating the dangerous world of the Dominators. His relationship with Lilith is complex, oscillating between hatred and a twisted sense of dependency, as he seeks a way to break free from her control.

The plot delves into themes of power, control, and the blurred lines between victim and perpetrator. Kaito's journey is marked by encounters with other Dominators and their thralls, each with their own agendas and tragic backstories. These interactions reveal the broader conflict among the Dominators and the devastating impact their manipulations have on the human world. The series explores the psychological toll of being under someone else's control, as well as the moral ambiguity of those who wield such power.

Supporting characters include other thralls who form alliances or rivalries with Kaito, as well as Dominators who challenge Lilith's authority. The narrative is driven by intense action sequences, emotional confrontations, and a steadily unfolding mystery about the origins and true nature of the Dominators. The story maintains a tense, foreboding atmosphere, with moments of graphic violence and psychological horror that underscore the high stakes of Kaito's struggle for freedom.