"Okitsune-sama de Chu" is a romantic comedy manga that centers on the relationship between a human boy and a fox spirit. The protagonist, a high school student named Kouta, encounters a mysterious fox spirit named Kon, who claims to be his wife. Kon is a playful and mischievous character, often using her supernatural abilities to meddle in Kouta's life. Despite her antics, she is deeply devoted to him, though Kouta initially struggles to understand her intentions and adapt to her presence.

The narrative explores the dynamics of their unconventional relationship, blending humor with moments of emotional depth. Kon's fox spirit heritage introduces elements of Japanese folklore, as she possesses abilities such as shape-shifting and creating illusions. These traits often lead to comedic situations, particularly when Kon's actions cause misunderstandings or chaos in Kouta's daily life. Over time, Kouta begins to develop feelings for Kon, though their relationship is complicated by her unpredictable nature and the cultural divide between humans and spirits.

Supporting characters include Kouta's classmates and friends, who occasionally become entangled in Kon's schemes. These interactions add layers to the story, highlighting the contrast between the mundane human world and the supernatural realm Kon inhabits. The manga balances lighthearted comedy with occasional moments of tension, particularly when Kon's actions inadvertently put Kouta in awkward or challenging situations.

Themes of love, loyalty, and the blending of two worlds are central to the narrative. Kon's unwavering affection for Kouta drives much of the plot, while Kouta's gradual acceptance of her presence reflects his growth as a character. The series maintains a focus on the evolving bond between the two protagonists, using humor and supernatural elements to explore their relationship in a way that is both entertaining and heartfelt.