In the Mikumagawa household, everyday life is anything but ordinary. The three sisters—Manaka, Rinka, and Yuuka—each bring a distinct personality to the family, turning even the simplest moments into comedy. Manaka, the eldest, is a college student with a calm, relaxed demeanor, though her clumsiness often lands her in trouble. Rinka, the middle sister, is a high schooler with a sharp tongue and a rough exterior, but underneath she genuinely cares for her siblings. The youngest, Yuuka, is a sharp-minded girl with a surprising talent for reciting the historical succession of shoguns while bathing. Their interactions, along with the kind yet quirky people who surround them, fill each day with laughter and small adventures.

The manga is composed of monthly full-color scenes that capture a wide range of situations—from holiday preparations and school life to chance encounters and playful mischief. Each chapter stands alone as a vignette, exploring themes of sisterly bonds, friendship, and the gentle absurdities of daily existence. The art is fully colored, and the tone balances lighthearted comedy with occasional ecchi humor. Across its sixty-two chapters, Melon Cream Soda offers a series of warm, amusing snapshots of three sisters navigating life together, with no overarching plot but a steady stream of charming episodes.