"Brave10 S" is a historical fantasy manga series that serves as a sequel to the original "Brave10." Set in feudal Japan during the Sengoku period, the story revolves around a group of ten warriors, known as the Sanada Ten Braves, who serve under the warlord Sanada Yukimura. These warriors are brought together to protect the Izumo shrine and its priestess, Isanami, who possesses a mysterious and powerful artifact known as the "Orochi's Eye." The artifact is sought after by various factions, including the Tokugawa shogunate and other rival clans, due to its potential to grant immense power.

The narrative begins with the aftermath of the original series, where the Sanada Ten Braves have disbanded. However, new threats emerge, forcing Yukimura to reassemble the group. The warriors, each with unique abilities and backgrounds, must navigate political intrigue, supernatural forces, and personal conflicts as they fight to protect Isanami and prevent the Orochi's Eye from falling into the wrong hands. Key characters include Saizo Kirigakure, a skilled ninja with a tragic past, and Isanami, whose connection to the artifact becomes increasingly significant as the story progresses.

The plot is driven by a series of battles and alliances, with the Ten Braves facing off against powerful enemies, including other skilled warriors and supernatural entities. The series explores themes of loyalty, honor, and the consequences of wielding great power. As the story unfolds, the characters' relationships and motivations are further developed, adding depth to the overarching conflict. The manga combines historical elements with fantastical elements, creating a rich and dynamic narrative that appeals to fans of both genres.