"Brave 10" is set in the tumultuous Sengoku period of Japan, a time of widespread conflict and political upheaval. The story centers on Saizo Kirigakure, a wandering ninja with a mysterious past, who becomes entangled in the ambitions of Isanami, a shrine maiden from the destroyed Izumo shrine. Isanami seeks revenge against the warlord Tokugawa Ieyasu, whom she believes is responsible for the massacre of her people. She enlists the help of Yukimura Sanada, a charismatic and ambitious warlord, who gathers ten powerful warriors, known as the Sanada Ten Braves, to protect her and challenge the Tokugawa forces.

The narrative unfolds as Saizo reluctantly joins Yukimura's cause, drawn by a sense of duty and a growing connection to Isanami. The Sanada Ten Braves consist of diverse and skilled individuals, each with unique abilities and backgrounds. Among them are Kamanosuke, a stoic swordsman; Sasuke Sarutobi, a cheerful and agile ninja; and Yuri Kamanosuke, a fierce and determined warrior. Together, they face numerous battles against Tokugawa's forces and other rival factions, navigating political intrigue, personal rivalries, and supernatural threats.

As the story progresses, the true nature of Isanami's powers is revealed, adding a layer of mysticism to the historical backdrop. Her abilities, tied to ancient gods and dark forces, become a focal point of the conflict, drawing the attention of powerful enemies. The series balances action-packed combat sequences with moments of character development, exploring the motivations and relationships within the group. Themes of loyalty, sacrifice, and the cost of ambition are woven throughout the narrative, as the Sanada Ten Braves strive to protect Isanami and shape the future of Japan. The plot builds toward a climactic confrontation, where alliances are tested, and the fate of the nation hangs in the balance.