"Iwa-Kakeru! -Climbing Girls-" centers on the world of competitive rock climbing, blending sports action with character-driven drama. The protagonist, Konomi Kasahara, is a high school student who stumbles upon the sport of rock climbing after transferring to a new school. Initially unfamiliar with the activity, she is drawn to its physical and mental challenges. The story explores her journey from a novice to a passionate climber, highlighting her growth as she learns techniques, overcomes fears, and builds camaraderie with her teammates.

The narrative introduces a diverse cast of characters, each with unique motivations and backgrounds. Sayo Yotsuba, a skilled and disciplined climber, serves as a mentor figure to Konomi, pushing her to improve while grappling with her own competitive pressures. Other teammates, such as the energetic Jun Uehara and the reserved Nonoka Sugiura, contribute to the dynamic group dynamic, showcasing different approaches to climbing and personal growth. The series also delves into rivalries with climbers from other schools, adding tension and stakes to the competitions.

The plot is structured around training sessions, climbing competitions, and personal challenges, with a focus on both individual and team achievements. Technical aspects of rock climbing, such as bouldering, lead climbing, and route-solving, are integrated into the story, providing an educational layer for readers unfamiliar with the sport. Themes of perseverance, teamwork, and self-discovery are woven throughout, as the characters navigate setbacks, injuries, and the pressures of competition.

"Iwa-Kakeru! -Climbing Girls-" balances its sports-centric narrative with moments of humor and slice-of-life elements, offering a well-rounded portrayal of its characters' lives. The series captures the excitement of climbing while emphasizing the importance of determination and mutual support, making it an engaging read for fans of sports manga and character-driven stories alike.