"Tamamo-chan's a Fox!" is a slice-of-life comedy manga centered around Tamamo, a young fox spirit who takes on a human form to live among humans. The story begins when Tamamo is discovered by a kind-hearted young man named Yoshio, who takes her in after finding her injured in the forest. Despite her mischievous and playful nature, Tamamo struggles to adapt to human life, often causing humorous misunderstandings due to her lack of familiarity with human customs and her inherent fox-like instincts.

The narrative explores Tamamo's daily life as she navigates the complexities of human society while trying to conceal her true identity. Her interactions with Yoshio and other characters, such as his friends and neighbors, form the core of the story. Tamamo's attempts to blend in often lead to comedic situations, as her fox traits—such as her love for fried tofu, her aversion to dogs, and her occasional transformations—frequently complicate matters.

Yoshio serves as a grounding presence, providing guidance and support as Tamamo learns to navigate her new life. Their relationship evolves from one of caretaker and ward to a deeper bond, though the story maintains a lighthearted tone, focusing on their everyday adventures rather than delving into heavy romantic themes. The supporting cast, including Yoshio's friends and other supernatural beings, adds variety to the narrative, introducing new dynamics and challenges for Tamamo to overcome.

The manga balances humor with moments of warmth, emphasizing themes of friendship, acceptance, and the blending of two worlds—human and supernatural. Tamamo's growth as a character is gradual, as she learns to appreciate human connections while staying true to her fox spirit heritage. The episodic structure of the series allows for a mix of standalone comedic scenarios and ongoing character development, creating a cohesive yet flexible narrative that appeals to fans of lighthearted, character-driven stories.