"Something's Wrong With Us" is a manga series that blends romance, drama, and mystery, set against the backdrop of traditional Japanese confectionery. The story centers on Nao, a skilled young wagashi artisan, who returns to the prestigious Tsubaki family's confectionery business after a 15-year absence. Her return is driven by a desire to uncover the truth behind her mother's wrongful conviction for the murder of the Tsubaki family patriarch, a crime she believes Nao's mother did not commit. Nao's mother died in prison, leaving Nao with a deep-seated need for justice.

The Tsubaki family, renowned for their exquisite wagashi, is now led by Tsubaki Kyoichi, Nao's childhood friend and the son of the murdered patriarch. Kyoichi, now a cold and enigmatic figure, initially appears to harbor resentment toward Nao, but their shared history and unresolved emotions complicate their interactions. As Nao works to prove her mother's innocence, she becomes entangled in the Tsubaki family's dark secrets, including betrayals, hidden motives, and long-buried scandals.

The narrative explores themes of revenge, loyalty, and the complexities of human relationships. Nao's determination to clear her mother's name often puts her at odds with Kyoichi, whose own motivations remain ambiguous. The tension between them is heightened by their mutual attraction, creating a volatile dynamic that oscillates between trust and suspicion. As the story progresses, layers of deception are peeled back, revealing the true nature of the Tsubaki family's power struggles and the events that led to the patriarch's death.

The supporting cast includes members of the Tsubaki household and rival confectioners, each with their own agendas and connections to the central mystery. The intricate plot is driven by Nao's relentless pursuit of the truth, even as she grapples with her growing feelings for Kyoichi and the moral dilemmas posed by her quest for vengeance. The series balances its dramatic and romantic elements with a meticulous portrayal of the art of wagashi-making, adding a unique cultural dimension to the story.