"Fortune Arterial" is a manga series set in a prestigious private academy called Shuchikan Academy, located on a remote island. The story centers on Kohei Hasekura, a transfer student who quickly becomes entangled in the mysterious and supernatural elements of the school. Upon his arrival, Kohei discovers that the student council president, Erika Sendo, is a vampire. This revelation sets the stage for a narrative that blends slice-of-life school dynamics with supernatural intrigue.

Erika, despite her vampiric nature, is a benevolent figure who refrains from feeding on humans, relying instead on blood packs provided by the school. Her existence is tied to a centuries-old curse that affects her family, and she seeks to break free from its constraints. Kohei, who possesses a unique ability to nullify supernatural powers, becomes a key figure in Erika's quest. His presence disrupts the delicate balance of the academy, drawing the attention of other supernatural entities and factions with their own agendas.

The story explores themes of coexistence between humans and vampires, as well as the moral dilemmas surrounding immortality and power. Kohei's relationships with other characters, including his childhood friend Haruna Yukishiro and the enigmatic Kuze Iori, add layers of complexity to the narrative. Haruna, who harbors feelings for Kohei, struggles with her own insecurities and the growing distance between them as he becomes more involved with Erika and the supernatural world. Kuze, a vampire hunter with a tragic past, serves as both an ally and a potential threat, embodying the tension between humans and vampires.

As the plot unfolds, Kohei and Erika work together to uncover the truth behind the curse and the academy's hidden secrets. Their journey is fraught with challenges, including confrontations with hostile vampires, political maneuvering within the vampire hierarchy, and the ethical implications of Erika's desire to become human. The story balances moments of lighthearted school life with darker, more intense sequences, creating a dynamic narrative that keeps readers engaged.

"Fortune Arterial" is characterized by its exploration of identity, loyalty, and the consequences of wielding power. The interplay between its characters, combined with the supernatural elements, creates a compelling tale that delves into the complexities of human and vampire relationships. The series maintains a steady pace, gradually revealing the intricacies of its world while keeping the focus on the personal growth and struggles of its protagonists.