"Girl Got Game" centers on Kyo Aizawa, a high school girl with exceptional basketball skills, who is forced to disguise herself as a boy to attend Seishu Gakuen, an all-boys school with a prestigious basketball program. This arrangement is orchestrated by her father, a former professional basketball player, who dreams of her becoming a star player. Kyo reluctantly agrees, adopting the name "Kyo Aizawa" and cutting her hair to pass as male.

At Seishu Gakuen, Kyo struggles to maintain her secret while navigating the challenges of living in a male-dominated environment. She joins the basketball team, where her talent quickly becomes evident, but her gender identity remains a constant source of tension. Her roommate, Chiharu Eniwa, a star player on the team, becomes a central figure in her life. Initially, Chiharu is hostile and suspicious of Kyo, but their relationship evolves as they spend more time together, leading to moments of camaraderie and conflict.

The series explores Kyo's efforts to balance her dual identity, her passion for basketball, and her growing feelings for Chiharu. Her interactions with teammates and classmates reveal the complexities of her situation, as she faces challenges such as rivalries, misunderstandings, and the constant fear of being discovered. The narrative delves into themes of identity, perseverance, and the pressures of living up to expectations, both from others and oneself.

Supporting characters, including teammates and rivals, add depth to the story, highlighting the competitive nature of high school basketball and the personal struggles each character faces. The series combines elements of sports, comedy, and romance, creating a dynamic and engaging narrative that keeps readers invested in Kyo's journey. Through her determination and resilience, Kyo strives to prove herself on the court while grappling with the emotional and social complexities of her hidden identity.