"Jigoku Sensei Nube Neo" is a continuation of the original "Jigoku Sensei Nube" series, focusing on the supernatural adventures of Meisuke Nueno, a teacher at Domori Elementary School who also battles demons and evil spirits. Nueno, known as Nube, possesses a demonic left hand sealed with a bandage, which grants him extraordinary powers to combat supernatural threats. The narrative revolves around Nube's dual role as an educator and a protector of his students from malevolent entities.

The story begins with Nube returning to Domori Elementary after a period of absence, resuming his duties as a fifth-grade homeroom teacher. His students, including the curious and brave Ritsuko Takahashi and the mischievous Miki Hosokawa, often find themselves entangled in supernatural incidents. Nube's unique abilities, combined with his deep sense of responsibility, drive him to confront these dangers head-on, ensuring the safety of his pupils.

Throughout the series, Nube encounters a variety of supernatural foes, ranging from vengeful spirits to powerful demons. Each arc typically involves a new threat that Nube must overcome, often requiring him to delve into the history and motivations of the entities he faces. The narrative explores themes of redemption, the consequences of human actions, and the importance of empathy and understanding.

Key characters include Nube's colleagues, such as the skeptical yet supportive Principal Tateno and the pragmatic school nurse Yukime, who often assist Nube in his battles. The series also introduces new adversaries and allies, expanding the supernatural world and adding depth to the ongoing conflict between good and evil.

"Jigoku Sensei Nube Neo" maintains the balance between horror and humor, with moments of intense action and lighthearted interactions among the characters. The series builds on the foundation of its predecessor, offering a fresh take on Nube's adventures while staying true to the core elements that defined the original. The narrative progresses through episodic arcs, each contributing to the overarching storyline and character development, ensuring a cohesive and engaging experience for readers.