"Cross Manage" is a sports-themed manga series centered around Sakurai, a high school student who becomes the manager of the girls' lacrosse team despite having no prior knowledge or interest in the sport. After a chance encounter with Misora, a member of the team, Sakurai is roped into the role by the team's coach, who sees potential in his ability to motivate and organize. The team, initially struggling with low morale and poor performance, begins to improve under Sakurai's guidance as he learns the intricacies of lacrosse and develops strategies to help the players.

The narrative explores the dynamics within the team, focusing on the individual struggles and growth of its members. Misora, the team's star player, initially resents Sakurai's involvement but gradually comes to respect his dedication and unconventional methods. Other key characters include the team captain, who balances leadership with her own insecurities, and various teammates who each bring unique personalities and challenges to the group. Sakurai's journey is marked by his transformation from an indifferent outsider to a passionate supporter of the team, as he navigates the complexities of teamwork, competition, and personal development.

The series blends elements of comedy, drama, and sports, with a strong emphasis on character interactions and the gradual progression of the team's skills and camaraderie. The lacrosse matches serve as pivotal moments, showcasing the team's growth and the impact of Sakurai's efforts. While the story primarily focuses on the team's journey, it also delves into Sakurai's personal life, including his relationships with classmates and his evolving sense of purpose. The manga concludes with the team achieving significant milestones, leaving a lasting impression of their hard work and determination.