"Boys Be... 2nd: A Guys Guide to Girls" is a continuation of the original "Boys Be..." series, focusing on the romantic and interpersonal relationships of a group of high school students. The narrative explores the complexities of young love, friendship, and the challenges of navigating adolescence. The story is structured as a series of interconnected vignettes, each centering on different characters and their experiences with romance and self-discovery.

The main characters include Kyoichi Kanzaki, a thoughtful and introspective boy who often finds himself caught in the middle of his friends' romantic entanglements, and Chiharu Kubota, a cheerful and outgoing girl who becomes a central figure in several of the storylines. Other key characters include Makoto Kurumizawa, a confident and athletic boy who struggles with his feelings for a childhood friend, and Yumi Saotome, a shy and reserved girl who gradually opens up as she becomes more involved with her peers.

The plot delves into various romantic scenarios, from unrequited love and misunderstandings to the excitement of new relationships. Each chapter typically focuses on a specific character or pair, highlighting their unique perspectives and emotional journeys. The series portrays the awkwardness and vulnerability of first loves, as well as the importance of communication and honesty in relationships. Themes of self-acceptance, personal growth, and the value of friendship are recurrent throughout the narrative.

The setting remains primarily within the high school environment, with occasional scenes in familiar locations such as parks, cafes, and homes. The interactions between characters are grounded in everyday situations, making the story relatable and accessible. The tone balances lighthearted moments with more serious reflections on the challenges of growing up, creating a well-rounded portrayal of teenage life.

"Boys Be... 2nd: A Guys Guide to Girls" builds on the foundation of its predecessor, offering a deeper exploration of its characters and their evolving relationships. The series maintains a focus on the emotional authenticity of its protagonists, capturing the nuances of their experiences with sensitivity and realism.