"Darling wa Namamono ni Tsuki" centers on the life of Aoi Nishimori, a high school student who becomes entangled in a supernatural romance after encountering a mysterious boy named Shigure. Shigure is revealed to be a "namamono," a being that exists between the human and spirit worlds, often taking on the form of a fox. His presence disrupts Aoi's ordinary life, as he claims she is his destined partner and begins to pursue her relentlessly. Despite her initial resistance, Aoi gradually finds herself drawn to Shigure, though their relationship is complicated by his unpredictable nature and the dangers that come with his supernatural existence.

The narrative explores the dynamics of their relationship as Aoi navigates the challenges of balancing her human life with the supernatural world Shigure inhabits. Shigure's possessiveness and lack of understanding of human emotions create tension, while Aoi struggles with her growing feelings for him and the consequences of being tied to a namamono. The story delves into themes of love, identity, and the boundaries between worlds, as Aoi learns more about Shigure's past and the reasons behind his attachment to her.

Supporting characters, such as Aoi's friends and other supernatural entities, add depth to the story, often serving as foils or obstacles to the central relationship. The manga blends elements of romance, comedy, and supernatural drama, with moments of lighthearted humor contrasting with darker, more intense scenes. As the plot progresses, Aoi and Shigure face external threats from other namamono and humans who seek to exploit or destroy their bond, forcing them to confront their feelings and the sacrifices required to stay together.

The series maintains a focus on character development, particularly Aoi's growth as she learns to assert herself and Shigure's gradual understanding of human emotions. The interplay between the human and supernatural worlds is a recurring motif, highlighting the challenges of bridging two fundamentally different realms. The story's pacing balances episodic conflicts with an overarching narrative, building toward a resolution that ties together the central themes and character arcs.