"Rikei ga Koi ni Ochita no de Shōmei Shite Mita" centers on two graduate students, Ayame Himuro and Shinya Yukimura, who are both researchers in the field of science. Himuro, a molecular biologist, and Yukimura, a neuroscientist, meet at a university laboratory and decide to conduct an experiment to determine whether their mutual attraction qualifies as love. They approach their feelings with the same rigorous methodology they apply to their scientific work, using experiments and data analysis to explore the nature of their emotions.

The narrative unfolds as the pair designs various tests to measure their compatibility, emotional responses, and physical reactions to each other. These experiments range from measuring heart rates during interactions to analyzing brain activity when they are together. Their scientific approach often leads to humorous and awkward situations, as they struggle to reconcile their logical minds with the unpredictable nature of romantic feelings.

Throughout the series, the relationship between Himuro and Yukimura evolves as they navigate the complexities of balancing their professional lives with their growing personal connection. Himuro is portrayed as confident and assertive, often taking the lead in their experiments, while Yukimura is more reserved and analytical, providing a counterbalance to her enthusiasm. Their dynamic is characterized by a blend of intellectual camaraderie and romantic tension, as they gradually come to understand that love cannot always be quantified or fully explained by science.

Supporting characters, such as their colleagues and friends, add depth to the story by providing external perspectives on the couple's relationship. These characters often serve as foils, highlighting the contrast between the protagonists' scientific approach to love and more conventional romantic experiences. The series explores themes of emotional vulnerability, the intersection of logic and emotion, and the challenges of maintaining a relationship while pursuing demanding careers.

The plot progresses through a series of episodic experiments and personal milestones, with each chapter delving into a new aspect of their relationship. The manga balances humor, romance, and scientific inquiry, creating a unique narrative that appeals to fans of both romantic comedies and intellectually driven stories. The characters' growth is central to the story, as they learn to embrace the uncertainties of love while staying true to their scientific principles.