"Science Fell in Love, So I Tried to Prove It. r=1-sinθ" is a romantic comedy anime that explores the intersection of love and scientific methodology. The story centers on Shinya Yukimura and Ayame Himuro, two graduate students in the field of science who share a mutual romantic interest but approach their feelings through the lens of empirical research. Yukimura, a reserved and logical individual, and Himuro, a confident and passionate researcher, decide to conduct experiments to determine whether their emotions can be quantified and proven scientifically.

The narrative unfolds as the pair designs various experiments to measure aspects of love, such as heart rate, physical proximity, and emotional responses. Their research often involves their fellow lab members, including Kosuke Inukai, a laid-back and supportive friend; Kanade Ibarada, a sharp and pragmatic colleague; and Ena Ibarada, Kanade’s younger sister, who provides a more lighthearted perspective. The series balances humor with the challenges of applying scientific rigor to something as subjective as love, often leading to comedic misunderstandings and heartfelt moments.

As the experiments progress, Yukimura and Himuro confront the limitations of their methods, realizing that love cannot be entirely reduced to data and formulas. Their journey explores themes of vulnerability, communication, and the complexities of human emotions, all while maintaining a focus on their academic and personal growth. The anime blends scientific concepts with romantic development, creating a unique narrative that appeals to fans of both genres. The title "r=1-sinθ" references a mathematical equation, symbolizing the series' thematic fusion of logic and emotion.