"Kyoudai Nyanko Suu & Kuu: Abarenbou Retsuden" centers on the lives of two anthropomorphic cat brothers, Suu and Kuu, who navigate a world filled with humor, chaos, and occasional danger. Suu, the older brother, is characterized by his calm demeanor and sharp intellect, often serving as the voice of reason. Kuu, the younger brother, is impulsive, hot-headed, and driven by a strong sense of justice, frequently landing the duo in trouble. Their contrasting personalities create a dynamic interplay that drives much of the series' comedic and dramatic tension.

The narrative unfolds in a bustling urban setting where the brothers take on various odd jobs and adventures, often involving encounters with eccentric characters and rival factions. Their primary goal is to survive and thrive in a world that is both familiar and strange, blending elements of everyday life with surreal, exaggerated scenarios. The brothers frequently clash with a rival gang led by a charismatic but ruthless figure, adding a layer of conflict and rivalry to the story. Despite their differences, Suu and Kuu share a deep bond, and their loyalty to each other is a recurring theme throughout the series.

The plot is episodic, with each chapter presenting a self-contained story that contributes to the overarching narrative. Themes of family, friendship, and perseverance are explored as the brothers face challenges ranging from mundane tasks to high-stakes confrontations. The series balances humor with moments of genuine emotion, creating a tone that is both lighthearted and occasionally poignant. The interactions between Suu and Kuu, as well as their relationships with supporting characters, provide depth and continuity, making the series engaging for readers.